A report will be prepared for the information of the Coroner following a fatal crash at Marulan.
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Just after 1pm Monday a Holden Barina and B-double collided on the Hume Highway about 1km south of Marulan.
A 74-year-old woman driving the Holden died at the scene.
The male truck driver was uninjured, but has been conveyed to hospital for mandatory blood and urine testing.
The southbound lanes are currently closed and traffic is utilising the breakdown lane to get past.
Reports from police indicate that traffic is moving very slowly in the breakdown lane and is banked up for more than 5 kms.
The RMS are advising drivers to exercise caution and expect major delays.
For more information on delays, motorists are advised to visit www.livetraffic.com for up-to-date traffic information.