Samu Kerevi will miss Australia's Test against Japan on Saturday with the barnstorming centre ruled out with an ankle injury in a huge blow for the Wallabies.
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Hunter Paisami will replace Kerevi in the No.12 jersey in his first match back since the All Blacks in August, when he left the Wallabies squad for the birth of his child.
Kerevi then proved impossible to dislodge during the Rugby Championship where he played a massive part in their four successive victories over world champions South Africa and Argentina.
However, he suffered a high ankle sprain in the Wallabies' final 32-17 win over the Pumas on the Gold Coast earlier this month.
Paisami is one of four changes to the starting XV with lock Matt Philip returning, his Rebels teammate Rob Leota recalled at blindside flanker and Tom Wright named on the wing in place of Marika Koroibete, who opted not to tour.
Nic White will again partner Quade Cooper in the halves, while the front row of James Slipper, Taniela Tupou and hooker Folau Fainga'a will line up for their fourth consecutive match.
Slipper is set to surpass former teammates Will Genia and Sekope Kepu and join George Smith on 111 Tests for Australia when he runs on.
Brumbies hooker Connal McInerney is in line for a potential Test debut after being named on the bench alongside prop Allan Alaalatoa, who is back from paternity leave.
Kerevi's explosive ability to get across the advantage line in the midfield was key to Australia's winning run but Wallabies coach Dave Rennie said Paisami was eager for another crack.
"While it's disappointing for Samu not to be able to play in Japan, Hunter started the first five Tests this year prior to the birth of his daughter and is chomping at the bit for another opportunity," Rennie said.
"We've got a huge amount of respect for the Brave Blossoms, who are now competitive with the best sides in the world.
"We'll need to be at our best."
The match will be played under the roof at Oita, which was the scene of their World Cup quarter-final elimination by England in 2019.
Wallabies: Reece Hodge, Tom Wright, Len Ikitau, Hunter Paisami, Andrew Kellaway, Quade Cooper, Nic White, Rob Valetini, Michael Hooper (c), Rob Leota, Matt Philip, Izack Rodda, Taniela Tupou, Folau Fainga'a, James Slipper. Res: Connal McInerney, Angus Bell, Allan Alaalatoa, Darcy Swain, Pete Samu, Tate McDermott, James O'Connor, Jordan Petaia.
Australian Associated Press