Emergency services were called to the Bourke and Clinton Street intersection at 1.03pm Friday where a vehicle and motorcycle had collided.

Acting Highway Patrol Inspector, Nicholas Parr said a 58-year-old Goulburn man, riding the bike, sustained serious leg injuries in the crash and was stabilised by paramedics at the scene before being airlifted to Canberra Hospital. A Toll helicopter landed on a vacant lot on the southeastern side of the intersection.

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His 29-year-old son, who was a pillion passenger on the bike, suffered serious head injuries and was stabilised at Goulburn ambulance station before being also airlifted to Canberra Hospital. A second Toll helicopter landed at Goulburn Base Hospital to transport him.

The motorbike had been heading east on Clinton Street when the collision occurred with a Toyota Landcruiser, travelling south on Bourke Street.

The 38-year-old female driver was not injured but was taken to Goulburn Base Hospital for mandatory blood alcohol and urine tests. Her two passengers, who were family members, were also uninjured.

Acting Inspector Parr said neither speed nor alcohol were factors in the crash. Detectives and crime scene officers are investigating the cause.

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Four ambulance crews, police and Goulburn's NSW Fire and Rescue crew attended the scene. Goulburn Mulwaree Council workers also closed Clinton and Bourke Streets around the crash.

While unrelated to this collision, Acting Inspector Parr reminded motorists not to drink drive and to be patient.

"This Easter is harder than others for people due to COVID and the floods etc," he said.

"People want to let their hair down but please, don't drink drive and have a plan B because there is nothing worse than us having to deal with drink drivers and fatalities."

He said motorists had been detected speeding on the Hume Highway around Goullburn on Friday morning, despite the start of Easter Operation, targeting road fatalities and trauma. The operation, involving high visibility policing, ends at midnight Monday.

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