Update: 2:10pm February 14
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The driver of the car is in a stable condition and has been transported by road to Goulburn Base Hospital.
Ambulance officers suspect the crash was caused by a medical episode.
1:30pm February 14
Emergency services are attending the scene of a car crash on the Federal Highway near Yarra.
The crash was reported at 12.49pm. A spokesperson for NSW Ambulance confirmed that three units are attending the scene, reportedly treating a man in his 50s for serious injuries.
One of two southbound lanes are closed, and emergency services advise caution.
Further updates will be posted as more information becomes available.